Treatment of severe auto/hetero aggressive behaviours in children and adolescents with autism spectrum disorder (ASD) is a complex issue. It is useful to treat symptoms as well as underlying psychiatric conditions or behavioural dysfunction. Symptomatic treatments include behavioural and family interventions and psychotropic medications, mostly sedative drugs, mood stabilizers and antipsychotics. To date, only a few atypical antipsychotics have been approved for minors to treat irritability and behavioural impairment associated with intellectual disability and/or pervasive developmental disorder, and such drugs have numerous adverse effects . In some resistant cases, clozapine , intensive behavioural intervention , electro-convulsive therapy (ECT) [4–5] or inpatient stays with a multidisciplinary approach  have been recommended, even in children and adolescents. The search for other therapeutic options is urgent.